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Enhancing Large Language Models for Clinical Decision Support by Incorporating Clinical Practice Guidelines

Oniani, David, Wu, Xizhi, Visweswaran, Shyam, Kapoor, Sumit, Kooragayalu, Shravan, Polanska, Katelyn, Wang, Yanshan

arXiv.org Artificial Intelligence

Background Large Language Models (LLMs), enhanced with Clinical Practice Guidelines (CPGs), can significantly improve Clinical Decision Support (CDS). However, methods for incorporating CPGs into LLMs are not well studied. Methods We develop three distinct methods for incorporating CPGs into LLMs: Binary Decision Tree (BDT), Program-Aided Graph Construction (PAGC), and Chain-of-Thought-Few-Shot Prompting (CoT-FSP). To evaluate the effectiveness of the proposed methods, we create a set of synthetic patient descriptions and conduct both automatic and human evaluation of the responses generated by four LLMs: GPT-4, GPT-3.5 Turbo, LLaMA, and PaLM 2. Zero-Shot Prompting (ZSP) was used as the baseline method. We focus on CDS for COVID-19 outpatient treatment as the case study. Results All four LLMs exhibit improved performance when enhanced with CPGs compared to the baseline ZSP. BDT outperformed both CoT-FSP and PAGC in automatic evaluation. All of the proposed methods demonstrated high performance in human evaluation. Conclusion LLMs enhanced with CPGs demonstrate superior performance, as compared to plain LLMs with ZSP, in providing accurate recommendations for COVID-19 outpatient treatment, which also highlights the potential for broader applications beyond the case study.


Breezeline Launches Innovative Streaming Video Service for Local Businesses

#artificialintelligence

Breezeline, the nation's eighth-largest cable operator, has launched Business Stream TV, a new, cloud-based video service designed to meet the needs of small and medium-sized businesses, their employees and customers. Business Stream TV uses advanced IPTV (Internet Protocol TV) technology to seamlessly integrate live TV, including local channels, streaming services like Netflix, Amazon Prime Video and YouTube, as well as popular sports apps, music services and more. Partners with ClusterPower to Unleash the Power of Artificial Intelligence Because Stream TV is cloud-based, it uses a sleek, 4" x 4" device, which saves space and is more energy efficient than traditional video equipment. Content from multiple sources is fully integrated into the Business Stream TV platform, which means it doesn't require switching between inputs or require multiple remotes. "Business Stream TV, when combined with Breezeline Business Internet, provides unmatched control and functionality for businesses and their teams," said Heather McCallion, Vice President of Products and Programming for Breezeline.


Inmate In South Carolina Prison Escapes Using Tools Dropped Off By Drone, Cell Phone

International Business Times

An inmate escaped a South Carolina maximum-security prison with the help of a drone. The individual, Jimmy Causey, was captured Friday after escaping on the 4th of July, officials said. Causey, 46, escaped in the evening of July 4 from the Lieber Correctional Institution, which is located in Ridgevilee, SC. However, officials didn't notice he was gone until the next day in the afternoon because he had used a dummy to fool guards. Causey managed to break free by using a cell phone, wire cutters and other tools that were dropped off by a drone, officials said according to the New York Times.